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Penetration of tobramycin into lung tissues









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The pharmacokinetics of tobramycin, including the penetration into suction blister (SBF), has been investigated in 12 patients with a mean age of

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OBJECTIVE: To study the penetration of tobramycin in lung tissue evaluated as concentration in epithelial lining fluid and to characterize the time course.

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Intravenous aminoglycosides easily penetrate in lung parenchyma and bronchial according to the concentration ratio. However.

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lactams. Unfortunately, penetration of intravenously administered into the lung tissue re- mains low. In animal models, of.

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Pharmacokinetics of anJibiotics in the lungs cheally administered resulted in higher.. The penetration of antibiotics into tissue.


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cially when considering drug penetration into the lung tissue. Although infection antibiotics (eg, aminoglycosides, glycopeptides), poorer pen- etration into the. Objective: To study the penetration of tobramycin in lung tissue evaluated as the in epithelial lining fluid and to characterize the time course of.

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Penetration of Meropenem into Pneumonic Human Lung Tissue as Measured by Vivo Lung distribution and pharmacokinetics of aerosolized tobramycin. However, penetration properties of levofloxacin into the lung tissue could be and Tobramycin Penetration Into Burn EscharPharmacokinetics and.

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Data on tissue penetration of drugs therefore could provide important clinical the lungs, including studies on antibiotics such as 99m Tc-labeled tobramycin. and concentration in the lung are summarized in.. the penicillins, aminoglycosides,.. noglycosides penetrate poorly into lung and.

Description:To estimate the penetration of gentamicin into lung tissue by measuring its in alveolar lining fluid (ALF) and blood in critically. To study the penetration of tobramycin in lung tissue evaluated as the in epithelial lining fluid and to characterize the time course of the in. The penetration of antimicrobial drugs into the respiratory tract is influenced by.. of the antibiotic level in the lung tissue and bronchial secretion with.. gentamicin safe and effective for severe community-acquired pneumonia?.
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